Clinical trials of new drugs for the treatment of rheumatoid arthritis: focus on early disease
Identifieur interne : 001C33 ( Main/Exploration ); précédent : 001C32; suivant : 001C34Clinical trials of new drugs for the treatment of rheumatoid arthritis: focus on early disease
Auteurs : Josef S. Smolen [Autriche] ; Sabine Collaud Basset [Suisse] ; Maarten Boers [Pays-Bas] ; Ferdinand Breedveld [Pays-Bas] ; Christopher J. Edwards [Royaume-Uni] ; Tore K. Kvien [Norvège] ; Pierre Miossec [France] ; Tuulikki Sokka-Isler [Finlande] ; Ronald F. Van Vollenhoven [Pays-Bas] ; Eric C. Abadie [France, Portugal] ; Olivier Bruyère [Belgique] ; Cyrus Cooper [Royaume-Uni] ; Heidi M Kinen [Finlande] ; Thierry Thomas [France] ; Peter Tugwell [Canada] ; Jean-Yves Reginster [Belgique]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2016.
Abstract
The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial methodology to comment on the new draft ‘Guideline on clinical investigation of medicinal products for the treatment of RA’ released by the European Medicines Agency (EMA). Special emphasis was placed by the group on the development of new drugs for the treatment of early RA. In the absence of a clear definition of early RA, it was suggested that clinical investigations in this condition were conducted in disease-modifying antirheumatic drugs naïve patients with no more than 1 year disease duration. The expert group recommended using an appropriate improvement in disease activity (American College of Rheumatology (ACR) or Simplified/Clinical Disease Activity Index (SDAI/CDAI) response criteria) or low disease activity (by any score) as primary endpoints, with ACR/European League Against Rheumatism remission as a secondary endpoint. Finally, as compelling evidence showed that the Disease Acrivity Score using 28-joint counts (DAS28) might not provide a reliable definition of remission, or sometimes even low disease activity, the group suggested replacing DAS28 as a measurement instrument to evaluate disease activity in RA clinical trials. Proposed alternatives included SDAI, CDAI and Boolean criteria.
Url:
DOI: 10.1136/annrheumdis-2016-209429
PubMed: 27037326
PubMed Central: 4941171
Affiliations:
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Smolen</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Internal Medicine III</addr-line>,<institution>Hietzing Hospital</institution>,<addr-line>Vienna</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Rheumatology</addr-line>,<institution>Medical University Vienna</institution>,<addr-line>Vienna</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Collaud Basset, Sabine" sort="Collaud Basset, Sabine" uniqKey="Collaud Basset S" first="Sabine" last="Collaud Basset">Sabine Collaud Basset</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>TRB Chemedica International SA</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boers, Maarten" sort="Boers, Maarten" uniqKey="Boers M" first="Maarten" last="Boers">Maarten Boers</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Amsterdam Rheumatology and Immunology Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breedveld, Ferdinand" sort="Breedveld, Ferdinand" uniqKey="Breedveld F" first="Ferdinand" last="Breedveld">Ferdinand Breedveld</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>Leiden University Medical Centre</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edwards, Christopher J" sort="Edwards, Christopher J" uniqKey="Edwards C" first="Christopher J" last="Edwards">Christopher J. Edwards</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Musculoskeletal Research Unit</addr-line>,<institution>NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kvien, Tore K" sort="Kvien, Tore K" uniqKey="Kvien T" first="Tore K" last="Kvien">Tore K. Kvien</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Rheumatology</addr-line>,<institution>Diakonhjemmet Hospital</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miossec, Pierre" sort="Miossec, Pierre" uniqKey="Miossec P" first="Pierre" last="Miossec">Pierre Miossec</name><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Clinical Immunology and Rheumatology, Immunogenomics and Inflammation Research Unit EA 4130</addr-line>,<institution>University of Lyon 1, Edouard Herriot Hospital</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sokka Isler, Tuulikki" sort="Sokka Isler, Tuulikki" uniqKey="Sokka Isler T" first="Tuulikki" last="Sokka-Isler">Tuulikki Sokka-Isler</name><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Faculty of Health Sciences</addr-line>,<institution>University of Eastern Finland, Jyvaskyla Central Hospital</institution>,<addr-line>Jyvaskyla</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. 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xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>NIHR Nutrition Biomedical Research Centre, University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af17"><institution>NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences</addr-line>,<institution>The Botnar Research Centre, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Kinen, Heidi" sort="M Kinen, Heidi" uniqKey="M Kinen H" first="Heidi" last="M Kinen">Heidi M Kinen</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Rheumatology Department</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Thierry" sort="Thomas, Thierry" uniqKey="Thomas T" first="Thierry" last="Thomas">Thierry Thomas</name><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Rheumatology Department</addr-line>,<institution>University Hospital of Saint-Etienne</institution>,<addr-line>Saint-Etienne</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><institution>INSERM U1059, Université de Lyon</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tugwell, Peter" sort="Tugwell, Peter" uniqKey="Tugwell P" first="Peter" last="Tugwell">Peter Tugwell</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Medicine</addr-line>,<institution>University of Ottawa</institution>,<addr-line>Ottawa</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name><affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Department of Public Health, Epidemiology and Health Economics</addr-line>,<institution>University of Liège</institution>,<addr-line>Liège</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial methodology to comment on the new draft ‘Guideline on clinical investigation of medicinal products for the treatment of RA’ released by the European Medicines Agency (EMA). Special emphasis was placed by the group on the development of new drugs for the treatment of early RA. In the absence of a clear definition of early RA, it was suggested that clinical investigations in this condition were conducted in disease-modifying antirheumatic drugs naïve patients with no more than 1 year disease duration. The expert group recommended using an appropriate improvement in disease activity (American College of Rheumatology (ACR) or Simplified/Clinical Disease Activity Index (SDAI/CDAI) response criteria) or low disease activity (by any score) as primary endpoints, with ACR/European League Against Rheumatism remission as a secondary endpoint. Finally, as compelling evidence showed that the Disease Acrivity Score using 28-joint counts (DAS28) might not provide a reliable definition of remission, or sometimes even low disease activity, the group suggested replacing DAS28 as a measurement instrument to evaluate disease activity in RA clinical trials. Proposed alternatives included SDAI, CDAI and Boolean criteria.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author><author><name sortKey="Abadie, Ec" uniqKey="Abadie E">EC Abadie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author><author><name sortKey="Abadie, Ec" uniqKey="Abadie E">EC Abadie</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Neogi, T" uniqKey="Neogi T">T Neogi</name></author><author><name sortKey="Silman, Aj" uniqKey="Silman A">AJ Silman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Wells, G" uniqKey="Wells G">G Wells</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Landewe, R" uniqKey="Landewe R">R Landewé</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Ja" uniqKey="Singh J">JA Singh</name></author><author><name sortKey="Saag, Kg" uniqKey="Saag K">KG Saag</name></author><author><name sortKey="Bridges, Sl" uniqKey="Bridges S">SL Bridges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Combe, B" uniqKey="Combe B">B Combe</name></author><author><name sortKey="Landewe, R" uniqKey="Landewe R">R Landewe</name></author><author><name sortKey="Lukas, C" uniqKey="Lukas C">C Lukas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Lavalley, Mp" uniqKey="Lavalley M">MP LaValley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author><author><name sortKey="Kostense, Pj" uniqKey="Kostense P">PJ Kostense</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Martinez Avila, J" uniqKey="Martinez Avila J">J Martinez-Avila</name></author><author><name sortKey="Kvien, Tk" uniqKey="Kvien T">TK Kvien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name></author><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kavanaugh, A" uniqKey="Kavanaugh A">A Kavanaugh</name></author><author><name sortKey="Fleischmann, Rm" uniqKey="Fleischmann R">RM Fleischmann</name></author><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Ward, Mm" uniqKey="Ward M">MM Ward</name></author><author><name sortKey="Machold, Kp" uniqKey="Machold K">KP Machold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Kinen, H" uniqKey="M Kinen H">H Mäkinen</name></author><author><name sortKey="Kautiainen, H" uniqKey="Kautiainen H">H Kautiainen</name></author><author><name sortKey="Hannonen, P" uniqKey="Hannonen P">P Hannonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bakker, Mf" uniqKey="Bakker M">MF Bakker</name></author><author><name sortKey="Jacobs, Jw" uniqKey="Jacobs J">JW Jacobs</name></author><author><name sortKey="Verstappen, Sm" uniqKey="Verstappen S">SM Verstappen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Beaulieu, A" uniqKey="Beaulieu A">A Beaulieu</name></author><author><name sortKey="Rubbert Roth, A" uniqKey="Rubbert Roth A">A Rubbert-Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author><author><name sortKey="Keystone, E" uniqKey="Keystone E">E Keystone</name></author><author><name sortKey="Tony, Hp" uniqKey="Tony H">HP Tony</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabay, C" uniqKey="Gabay C">C Gabay</name></author><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author><author><name sortKey="Van Vollenhoven, R" uniqKey="Van Vollenhoven R">R van Vollenhoven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Rigby, Wf" uniqKey="Rigby W">WF Rigby</name></author><author><name sortKey="Van Vollenhoven, Rf" uniqKey="Van Vollenhoven R">RF van Vollenhoven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genovese, Mc" uniqKey="Genovese M">MC Genovese</name></author><author><name sortKey="Becker, Jc" uniqKey="Becker J">JC Becker</name></author><author><name sortKey="Schiff, M" uniqKey="Schiff M">M Schiff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Sb" uniqKey="Cohen S">SB Cohen</name></author><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author><author><name sortKey="Greenwald, Mw" uniqKey="Greenwald M">MW Greenwald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author><author><name sortKey="Kremer, J" uniqKey="Kremer J">J Kremer</name></author><author><name sortKey="Cush, J" uniqKey="Cush J">J Cush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Gruben, D" uniqKey="Gruben D">D Gruben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Nell, Vp" uniqKey="Nell V">VP Nell</name></author><author><name sortKey="Stamm, T" uniqKey="Stamm T">T Stamm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pincus, T" uniqKey="Pincus T">T Pincus</name></author><author><name sortKey="Furer, V" uniqKey="Furer V">V Furer</name></author><author><name sortKey="Keystone, E" uniqKey="Keystone E">E Keystone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curtis, Jr" uniqKey="Curtis J">JR Curtis</name></author><author><name sortKey="Churchill, M" uniqKey="Churchill M">M Churchill</name></author><author><name sortKey="Kivitz, A" uniqKey="Kivitz A">A Kivitz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Finlande</li><li>France</li><li>Norvège</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>Suisse</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name></noRegion><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name></country><country name="Suisse"><noRegion><name sortKey="Collaud Basset, Sabine" sort="Collaud Basset, Sabine" uniqKey="Collaud Basset S" first="Sabine" last="Collaud Basset">Sabine Collaud Basset</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Boers, Maarten" sort="Boers, Maarten" uniqKey="Boers M" first="Maarten" last="Boers">Maarten Boers</name></noRegion><name sortKey="Boers, Maarten" sort="Boers, Maarten" uniqKey="Boers M" first="Maarten" last="Boers">Maarten Boers</name><name sortKey="Breedveld, Ferdinand" sort="Breedveld, Ferdinand" uniqKey="Breedveld F" first="Ferdinand" last="Breedveld">Ferdinand Breedveld</name><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Edwards, Christopher J" sort="Edwards, Christopher J" uniqKey="Edwards C" first="Christopher J" last="Edwards">Christopher J. Edwards</name></noRegion><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name></country><country name="Norvège"><noRegion><name sortKey="Kvien, Tore K" sort="Kvien, Tore K" uniqKey="Kvien T" first="Tore K" last="Kvien">Tore K. Kvien</name></noRegion></country><country name="France"><noRegion><name sortKey="Miossec, Pierre" sort="Miossec, Pierre" uniqKey="Miossec P" first="Pierre" last="Miossec">Pierre Miossec</name></noRegion><name sortKey="Abadie, Eric C" sort="Abadie, Eric C" uniqKey="Abadie E" first="Eric C" last="Abadie">Eric C. Abadie</name><name sortKey="Thomas, Thierry" sort="Thomas, Thierry" uniqKey="Thomas T" first="Thierry" last="Thomas">Thierry Thomas</name><name sortKey="Thomas, Thierry" sort="Thomas, Thierry" uniqKey="Thomas T" first="Thierry" last="Thomas">Thierry Thomas</name></country><country name="Finlande"><noRegion><name sortKey="Sokka Isler, Tuulikki" sort="Sokka Isler, Tuulikki" uniqKey="Sokka Isler T" first="Tuulikki" last="Sokka-Isler">Tuulikki Sokka-Isler</name></noRegion><name sortKey="M Kinen, Heidi" sort="M Kinen, Heidi" uniqKey="M Kinen H" first="Heidi" last="M Kinen">Heidi M Kinen</name></country><country name="Portugal"><noRegion><name sortKey="Abadie, Eric C" sort="Abadie, Eric C" uniqKey="Abadie E" first="Eric C" last="Abadie">Eric C. Abadie</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Bruyere, Olivier" sort="Bruyere, Olivier" uniqKey="Bruyere O" first="Olivier" last="Bruyère">Olivier Bruyère</name></noRegion><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name></country><country name="Canada"><noRegion><name sortKey="Tugwell, Peter" sort="Tugwell, Peter" uniqKey="Tugwell P" first="Peter" last="Tugwell">Peter Tugwell</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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